Amnesty International said the often harsh and inhumane conditions at the camp were “pushing people to the edge”.
It called for the facility to be closed and for plans for “unfair” military commission trials to be abandoned.
Many of the 385 inmates have been held for five years or more, unable to mount a legal challenge to their detention.
“While the United States has an obligation to protect its citizens… that does not relieve the United States from its responsibilities to comply with human rights,” the report said.
“Statements by the Bush administration that these men are ‘enemy combatants,’ ‘terrorists’ or ‘very bad people’ do not justify the complete lack of due process rights,” the group said.